Five classifications. One consistent vocabulary.
How AES separates established science, supported findings, emerging hypotheses, mechanistic reasoning and areas where evidence is not established.
Established
Consistent and relevant evidence with a high level of confidence for the specific use, formulation and population.
Supported
Reasonably consistent human evidence with some limitations in design, replication or applicability.
Emerging
Promising human evidence that remains preliminary, limited or inconsistent.
Mechanistic
Biological plausibility or preclinical evidence without sufficient direct human outcome evidence.
Not Established
Evidence is absent, insufficient, irrelevant or conflicting for the specific claim.
What these classifications are not.
They are AES internal evidence classifications used to govern public language. They are not clinical grades and do not constitute medical advice.