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Methodology

How we assess evidence.

The seven-step evidence process AES uses to evaluate ingredients, formulations and claims — from question definition through approved public language.

DisclosureWe use the term structured evidence review unless a formal systematic-review process has been completed. AES does not label internal reviews as systematic reviews.
01

Define the question

Every review begins with a written question capturing ingredient, ingredient form, quantity, population, intended outcome, duration, comparison and relevant safety considerations.

02

Search the evidence

Searches record the date, search terms, databases, inclusion and exclusion criteria, reviewer and next search update date.

03

Assess relevance

Studies are only credited to a claim when they match the exact ingredient, chemical form, quantity, product format, population, duration and outcome.

04

Assess study quality

Design, sample size, comparator, blinding, duration, outcome quality, attrition, funding, conflicts of interest, replication, statistical limitations and generalisability are recorded per study.

05

Separate evidence levels

EstablishedConsistent and relevant evidence with a high level of confidence for the specific use.
SupportedReasonably consistent human evidence, with some limitations.
EmergingPromising human evidence that remains preliminary, limited or inconsistent.
MechanisticBiological plausibility or preclinical evidence without sufficient direct human outcome evidence.
Not EstablishedEvidence is absent, insufficient, irrelevant or conflicting.

These are internal evidence classifications, not clinical grades.

06

Document limitations

Every summary states what is known, what remains uncertain, whether the exact product was studied, whether the quantity matches, whether the population is comparable, key safety limitations and the date of review.

07

Approve public language

Claims are only published with a source record, evidence classification, regional approval, scientific review, regulatory review and a reassessment date.

Framework

Read the evidence framework →

A companion page defines each classification, the review cadence and the correction process.